Modeling the metabolic trajectory of patients with type 1 diabetes using digital twins and markov models

Thesis Proposal Details

Supervisor: Giacomo Cappon

Co-supervisor: Luca Cossu

Co-supervisor Department/Company: DEI

Creation Date: 08/07/2025 13:35

Description

This work proposes a data-driven approach to model the metabolic trajectory of patients with Type 1 Diabetes by integrating Digital Twin technology and Markov models. Using a dataset of 14,888 patient records, I| first clustered the data to identify distinct metabolic profiles. From these clusters, I derived Markov models to capture probabilistic transitions between metabolic states. The models were then used to generate synthetic daily trajectories, which were simulated in ReplayBG.

Dataset and methods

Dataset type: Already acquired data

Dataset description: 14,888 daily records of people with type 1 diabetes including continuous glucose monitoring, insulin injections, and meal intakes.

List of Methods: Digital Twins Markov Models Clustering Techniques

Preparatory Courses

Analisi dei Dati Biologici Machine Learning

Tags
digitaltwin markovmodels matlab python tidepool type1diabetes
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