Supervisor: Chiara Dalla Man
Co-supervisor: Jacopo Bonet
Co-supervisor Department/Company: DEI
Creation Date: 31/10/2025 09:42
GLP-1 is a powerful insulin secretagogue secreted by intestine L-cells. A model of GLP-1 action of pancreatic beta cells alredy exists.
Converseley, a mathematical model describing GLP-1 secretion by the intestine is lacking.
The aim of this thesis is to fill this gap.
To do that data of post-prandial glucose rate of appearance and GLP-1 plasma concnetration will be used.
Dataset type: Already acquired data
Dataset description: Plasma glucose, insulin, C-peptide, GLP-1 concentrations and tracer-derived Ra time courses in 62 individuals with various degree of glucose tolerance
List of Methods: Model identification techniques.
Modeling Methodology for Physiology and Medicine